Raman imaging for measuring homogeneity of dry binary blend: Combining microscopy with spectroscopy for technologists

Near-infrared spectroscopy and imaging for the monitoring of powder blend homogeneity.

In-process testing requirements for adequacy of mixing are established in 21 CFR 211.110(a)(3). Considering also, the U.S. Food and Drug Administration's draft guidance published in 1999 (Guidance for Industry, ANDAs: Blend Uniformity Analysis; http://www.fda.gov/cder/guidance/index.htm), the importance of when and how to perform blend uniformity analysis is obvious. Near-infrared (NIR) spectro...

High Performance Method for Skin Roughness Detection Using Raman Spectroscopy

Combining scanning haptic microscopy and fibre optic Raman spectroscopy for tissue characterization.

The tactile resonance method (TRM) and Raman spectroscopy (RS) are promising for tissue characterization in vivo. Our goal is to combine these techniques into one instrument, to use TRM for swift scanning, and RS for increasing the diagnostic power. The aim of this study was to determine the classification accuracy, using support vector machines, for measurements on porcine tissue and also prod...

Combined Scanning Probe Microscopy and Confocal Raman Spectroscopy for Functional Imaging of the Layered Materials

Comprehensive investigations of the nano-structured materials and devices are impossible without development of the modern investigative techniques, allowing noninvasive imaging of the processes defining materials functionality on the nanoscale. Scanning probe microscopy (SPM) is one of such paradigmatic tools. Since its development, about thirty years ago, it has given rise to numerous ancilla...

Fluorescence modeling for optimized-binary compressive detection Raman spectroscopy.

The recently-developed optimized binary compressive detection (OB-CD) strategy has been shown to be capable of using Raman spectral signatures to rapidly classify and quantify liquid samples and to image solid samples. Here we demonstrate that OB-CD can also be used to quantitatively separate Raman and fluorescence features, and thus facilitate Raman-based chemical analyses in the presence of f...